4mmc only Ethylacetaat or tolueen

[Studenttt]

is this a possible synthesis?
I do not use NMP but only Ethylacetaat or tolueen



Synthesis

1.
1 kg 2-bromo-4-methylpropiophenone (BK4) added to the reactor.

2.
2 liters Ethylacetaat or tolueen poured, start stirring and heating to 40 *C.

3.
Upon reaching 40 *C within the mixture, pour 2 liters methyl amine 40% aq.soln and continue stirring 20 minutes.

4.
Next, we pour 2 liters of clean cold water, stirring a few minutes.

6.
Stop stirring, waiting for the separation of the mixture into two layers. The bottom aqueous layer was drained through the bottom valve of the reactor.

8.
2 liters of ice acetone was poured and add hydrochloric acid with stirring to pH - 5
Overload the mixture in the freezer.
Filter on the nutshe-filter, dry.

 

[Didi]

Made and u Will see then u can tell as is ok syntesis simple.

 

[Studenttt]

Yes i gone try, but is it chemistry possible white only tolueen or Ethylacetaat. Or do I need a polar solvent/Aprotic solvents

 

[Didi]

U can use this and this

 

[Serega]

better use toluene. ethyl acetate gives a dirtier product due to gumming during the reaction of the ketone with methylamine.

 

[Studenttt]

Thank you