Amph sulphate or phosphate?

[MadHatter]

What is the actual difference between these two salts? I can deduct from calculations that the sulphate form would contain more amphetamine per weight, and that the phosphate salt should be easier soluble in water, but is there an actual difference in macroscopic properties between them? How about hygroscopy? I really only have experience with the sulphate form, but in what way will the end product differ if it's produced by addition of phosphoric acid in the final step?

 

[Sasha89]

Das würde mich auch sehr interessieten

 

[Marvin "Popcorn" Sutton]

Here's an interesting topic about amphetamine salts

 

[MadHatter]

Yes, that is interesting and very well-written, thank you! I had missed that one.

Alas, it doesn't really answer my questions. It is mostly an exposé about enantiomers, with a brief introduction about the salt forms.
So my question remains: what are the important differences in physical properties between amphetamine sulphate and phosphate, and how do they affect handling, storage and usage?

And no, I don't mean bioeffects. Anyone who starts dribbling about them having different effects in the body has just exposed his own incompetence and will be ignored or possibly ridiculed.

 

[William D.]

Phosphate melting point below, it is more demanding to long-term storage conditions.

 

[MadHatter]

Thank you W! But may I ask why? More hygroscopic?

 

[Barterpayne]

I have synthesiszed Phosphate last week .. Phosphaste effect kick faster (15 minutes ) , phosphate effect last much longer ! And sometimes it is boring cause you need to come down .
The phosphate effect is less effective intranasally.

 

[Barterpayne]

Phosphate has the worse secondary effect which is : short term memory loss .
Sulfate doesn't induce memory loss , but when you go 150 mg onto Phosphaste, the effect kick and come with lot of short term memory loss while working on some task . And this memory loss become so obvious and predictable by yourself .

 

[William D.]

Pharmaceutical salt - sulfate. If possible, I think need to use this. Phosphate is used mainly when there are problems with the purchase of sulfuric acid.