can bromination of crude 4 methyl propiophenone be done?

[Zenithberserker]

So while making bromoketone you have to add 4 methyl propiophenone to Hbr and use hyd peroxide for bromination.

now the thing is, I have done this before when I bought methylpropiophenone from a vendour but this time I am synthesizing it on my own from scratch

so for now I have synthesized propionyl chloride and I have toluene and aluminium chloride anhydrous


I can reach upto the step where I will put the reaction mixture into ice and hcl and then remove the solvent layer and distill it off but apparently as the video suggested if I get the crude 4 methyl propiophenone will it suffice for bromination purpose? i cannot vaccum distill it as I cannot afford a vaccum pump for now and other thing is I cant buy 4mp because a lot of kyc in my country

 

[w2x3f5]

For the acetylation reaction, low temperature is important, there are also a number of conditions for obtaining a pure substance at the output. In next step I would also brominate the methylpropiophenone complex with aluminum chloride, this will potentially give the highest yield and excellent purity of the product, the reaction conditions and the purity of 4-methylpropiophenone from the acetylation reaction are also important.

 

[Dr. MMX]

Consideer making 3cmc, it has a lot of easier oprecursor to do - literallyu anything "no risk" purchaches and syntehsis seems to be very easy compared to not quite nice job with propionyl chloride

 

[JosephBratan]

? What is more hard?
These proesses are completly different. For 3 chloropropiophenone you may actually buy it eerywhere to syntehtise, for 4mp its rare regants that you can buy

 

[Dr. MMX]

? What is more hard?
These proesses are completly different. For 3 chloropropiophenone you may actually buy it eerywhere to syntehtise, for 4mp its rare regants that you can buy

 

[William D.]

You can use dcm as a solvent for acylation. In dcm, you can rinse the 4mp and bromination in the same solvent. It may not be so pure, but it is possible. We can take dcm at the beginning, so as not to use the excess of toluene and the reaction go in milder conditions.