Help with extraction of pseudoephedrine 30mg
- Thread starter OxycodoneHCL
- Start date
The drug you described is too vague to accurately describe the problem, 200 milligrams of ibuprofen and 30 milligrams of PSE. What other filling ingredients are there? Are they tablets or pills or liquids? Does it contain drugs to prevent the extraction of PSE?
My bad 
the following inactive ingredients are Tablet core Microcrystalline cellulose Calcium hydrogen phosphate anhydrous Croscarmellose sodium Maize starch Silica, colloidal anhydrous Magnesium stearate Tablet coating Hypromellose Macrogol 400 Talc Titanium dioxide (E171) Iron oxide yellow (E172)
the following inactive ingredients are Tablet core Microcrystalline cellulose Calcium hydrogen phosphate anhydrous Croscarmellose sodium Maize starch Silica, colloidal anhydrous Magnesium stearate Tablet coating Hypromellose Macrogol 400 Talc Titanium dioxide (E171) Iron oxide yellow (E172)
The inactives are more or less irrelevent - we're just going to get rid of the whole mess! You can use methanol or IPA to extract the pseudo. This is going to bring the ibuprofen over with it, and it will be the majority of what is left after you filter and evaporate your extractions. All we have to do now is a simple cold-water extraction. Have you ever made codeine or vicodin juice? Same idea...
We take everything and dissolve it into cold water - try not to use that much - or just the right amount because you either have to let it dry or will have to reduce it, depending on what you are planning on doing with it next. Anyway, dissolve it into cold water and stick it in the freezer. After 30 mins or so, when it gets as cold as it is gonna get and everything solid sinks to the bottom, you can decant the solution and filter - seperating the ibuprofen from the water/pseudo solution. Let it dry or proceed to the cook ...
Take care,
o7
We take everything and dissolve it into cold water - try not to use that much - or just the right amount because you either have to let it dry or will have to reduce it, depending on what you are planning on doing with it next. Anyway, dissolve it into cold water and stick it in the freezer. After 30 mins or so, when it gets as cold as it is gonna get and everything solid sinks to the bottom, you can decant the solution and filter - seperating the ibuprofen from the water/pseudo solution. Let it dry or proceed to the cook ...
Take care,
o7
- By OxycodoneHCL
When you say everything solid you mean pseudoephedrine will fall out and the ibuprofen will stay dissolved?
No, the pseudo is going to dissolve into the alcohol, along with some other things, mostly ibuprofen. We can cool it down first, and decant the majority of it. So then we filter, wash the solids a little bit to get everything we might have left behind and then we get rid of the solids. The filtered alcohol solution that has our pseudo. Depending on how well we filtered we can just evaporate the alcohol, or if its more cloudy stick it in the freezer (again?) for a while and any ibuprofen will collect at the boittom. Try filtering with a cotton in the neck of the funnel instead of coffee filter(s). Gravity fed filter with cotton filters very well, it just takes a while.
Uhh the inactive ingredients are the most important bit of information a person can have when extracting from pills. Using water on most pills nowadays will cause them to swell up and slowly release the active ingredient. Also the pills today can't just simply be ground to a powder and extracted with ethanol because of the matrix formulation of them. Meaning the shit holding onto the pseudoephedrine will still be holding onto it after a simple extraction. Doing an AB doesn't do anything either because the binder isn't bothered by pH. I don't know if it would crystalize correctly because of the binder, I doubt it though.
That binder/ polymer holding onto the pseudoephedrine needs to be dealt with before the pseudoephedrine is accessible and able to be reduced.
MCC is the first thing that pops out to me as the binder which causes it to swell. Also any pills that have a coating that is acting as a shell, like this pill, needs to be removed first. Otherwise it is going to just hinder what you're attempting to do.
Tetrachloroethylene might help you out.
The 3 types of matrix pills ("hydrophilic matrix" are also known as "dry matrix")
That binder/ polymer holding onto the pseudoephedrine needs to be dealt with before the pseudoephedrine is accessible and able to be reduced.
MCC is the first thing that pops out to me as the binder which causes it to swell. Also any pills that have a coating that is acting as a shell, like this pill, needs to be removed first. Otherwise it is going to just hinder what you're attempting to do.
Tetrachloroethylene might help you out.
The 3 types of matrix pills ("hydrophilic matrix" are also known as "dry matrix")
- Hydrophilic Matrix Tablets: These contain water-soluble polymers that swell in the presence of water, creating a gel layer that controls the drug release rate.
- Lipophilic Matrix Tablets: Made with water-insoluble polymers, these tablets release their contents by slowly eroding in the digestive tract.
- Bi-layer Matrix Tablets: These are composed of two layers with different release profiles, typically one immediate and one extended-release layer, allowing for dual drug release kinetics or fixed-dose combinations (two drugs in one tablet).