A high yielding synthesis of oxymorphone via entirely catalytic means:
Posting here too bcs i think it deserves that.
The following synthesis has been tested and tried by SWIM to make oxymorphone
Oxycodone should be the same and im here to help with that however i have not attempted it
Reagent list:
20g morphine or 21g codeine
190ml water
1g PdCl2 (platinum salts also workies :3)
12.4g sodium thiosulfate
4g manganese sulfate
2.6g calcium phosphate
Some hcl
some NaOH
Say 75ml ethanol
HYDROMORPHONE
20g morphine (or 21g codeine) was dissolved in 40ml water, slightly acidified with hcl and 1g PdCl was added the solution was then refluxed for 6hrs.
Next the palladium was filtered off and the acid filtrate was basified with NaOH. The hydromorphone base which separated was dissolved in a minimal amount of ethanol, acidified with hcl and the solvent removed in vacuo
****Mew sidenote here:**** i usually recrys from something like ethanol but as hydromorph*one* is a ketone, it can form a bisulfite adduct and ive had much success with that"
OXYMORPHONE
(For oxycodone swap for 11.5g hydrocodone)
11.5g hydromorphone, 12.4g sodium thiosulfate and 4g MnSO4 is added to a solution of 2.6g CaH2PO4 in 150ml water this is stirred at highspeeds with a pump blowing air into the flask for 6hrs at 30-35°C then the solvent is removed in vacuo and to the solids is added 50ml ethanol the solution filtered and the ethanol removed in vacuo to leave oxymorphone
Can do oxidising faster if you have pure o2 running throo it tho havent acc attempted the oxycodone one myself ngl cos oxymorphones so much more fun... :3333 ^^^^w^^^^^
I am planning on making a synthesis vid of both for yall i just dont have the funds right now (girlie needs a sugar daddy ughhhhh :c)
Oh source zhang 2005 JACS 14-Hydroxylation of Opiates: Catalytic Direct Autoxidation of Codeinone to 14-Hydroxycodeinone
Posting here too bcs i think it deserves that.
The following synthesis has been tested and tried by SWIM to make oxymorphone
Oxycodone should be the same and im here to help with that however i have not attempted it
Reagent list:
20g morphine or 21g codeine
190ml water
1g PdCl2 (platinum salts also workies :3)
12.4g sodium thiosulfate
4g manganese sulfate
2.6g calcium phosphate
Some hcl
some NaOH
Say 75ml ethanol
HYDROMORPHONE
20g morphine (or 21g codeine) was dissolved in 40ml water, slightly acidified with hcl and 1g PdCl was added the solution was then refluxed for 6hrs.
Next the palladium was filtered off and the acid filtrate was basified with NaOH. The hydromorphone base which separated was dissolved in a minimal amount of ethanol, acidified with hcl and the solvent removed in vacuo
****Mew sidenote here:**** i usually recrys from something like ethanol but as hydromorph*one* is a ketone, it can form a bisulfite adduct and ive had much success with that"
OXYMORPHONE
(For oxycodone swap for 11.5g hydrocodone)
11.5g hydromorphone, 12.4g sodium thiosulfate and 4g MnSO4 is added to a solution of 2.6g CaH2PO4 in 150ml water this is stirred at highspeeds with a pump blowing air into the flask for 6hrs at 30-35°C then the solvent is removed in vacuo and to the solids is added 50ml ethanol the solution filtered and the ethanol removed in vacuo to leave oxymorphone
Can do oxidising faster if you have pure o2 running throo it tho havent acc attempted the oxycodone one myself ngl cos oxymorphones so much more fun... :3333 ^^^^w^^^^^
I am planning on making a synthesis vid of both for yall i just dont have the funds right now (girlie needs a sugar daddy ughhhhh :c)
Oh source zhang 2005 JACS 14-Hydroxylation of Opiates: Catalytic Direct Autoxidation of Codeinone to 14-Hydroxycodeinone