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1. Vape It
Vaporizing DMT is the simplest method of using it. There are two main ways to do this:
Make a DMT-charged E-Liquid — dissolve the powder into an E-liquid base (readily available online) and then fill an E-liquid vape pen with the DMT-charged E-juice. You can make the juice as strong as you want, but the most common ration is 1:1. This means you should add about 1 gram of DMT powder for every 1 mL of E-liquid.
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Vape raw DMT powder in a mesh or mod vape pen — These devices contain a stainless steel mesh that holds the powder above the heating element. This is the best method for single-hit breakthroughs. The downside is that these devices are more expensive and take some finessing to get them to work properly.
2. Smoke It
DMT can be smoked in a pipe or bong. It’s going to be very harsh no matter how you smoke it. Some people like to use the crack-style pipes to smoke DMT because they can control the temperature of it better than having to put the flame on it directly.
Never use DMT powder without weighing it first. This stuff is exceptionally strong.
3. Eat It
If you eat DMT powder directly, nothing will happen. You need to mix it with a monoamine oxidase inhibitor first for it to work.
This is some tricky business and not something anybody should attempt without adequate knowledge and oversight from experienced users. There are two categories of MAO inhibitors to consider — herbal MAO inhibitors and pharmaceutical MAO inhibitors.
The preparation most people use for this is called pharmahuasca. The concept simulates ayahuasca using synthetic ingredients. This means mixing DMT with a prescription MAO inhibitor like Isocarboxazid (Marplan). This combination can be dangerous — Marplan is a powerful drug with a long list of potential side effects.
Herbal options include Syrian Rue and Ayahuasca vine. They can be made into a very strong tea and mixed with DMT. The experience using this method will range substantially from being not psychoactive at all to powerfully psychoactive.