Isomerisierung von Cannabidiol (CBD) zu psychoaktiven Cannabinoiden

[Rabidreject]

Yeah I did get a little oil. Just hardly any, I did use heat and I kept adding brine.
I suspect if I’d run it for a lot longer I would have been more efficient.

My plan of action going forward is just to whip up some p-TSA and then use that at different temperatures to control my d8/D9 ratios. I just picked up a deanstark trap to run the solfonicatjon of toluene. I think that’s the correct terminology, I have looked into the reaction.
Anyway, I cleaned up and samples some of the oil I did obtain so I’ll see if it was actually THC that was produced in small doses quantity (or other active cannabinoids) but it does look and feel exactly like any distillate (be is d9 or d8) that I have had before so

 

[William D.]

If you want to use pTSA, check out (this) synthesis. If this is not convenient for you, I will provide additional advice.

 

[William D.]

I don't think you'll have to deal with water formation.

 

[Rabidreject]

Okay well yeah I made some p-tsa. I used a dean stark trap but yeah you may be correct in that it looked like I added the same amount of water at the end (to make the monohydrate salt) as the dean stark trap removed so likely you could do it without and it may just form the monohydrate.
I must admit it was pretty dirty to begin with (I obviously need to distil my sulfuric) but after washing it loads it came clean in the end.
I am now running this CBD isomerisation with p-tsa at room temp as iv been lead to believe that it’s more likely to selectively isomerise to d9 (or at least have more in the mix). I saw someone did it at 40c for 4 hours in an US-bath to make roughly a 60:40 ratio of d8 to d9, so I decided to do it at RT for around 6 hours but I’ll test for CBD to see if that’s long enough

 

[William D.]

I think you have seen the same method in toluene, which is more selective. If you have the opportunity to buy toluene, it is worth trying. But with ultrasound, unfortunately there is no such data, only a reduced temperature is possible.