What if I gonna replace NMP with DMF? Somebody tried? What proportion of DMF should be used if in use instead DMF?
Somebody have the stirring timings and than other timings for those synthesis description? It looks very interesting, I will be appreciate.
Somebody have the stirring timings and than other timings for those synthesis description? It looks very interesting, I will be appreciate.
- By William D.
DMF can be used like DMSO, but yield and some other conditions may differ.
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- By wikimiki
William thanks a lot but could you tell me how much differ your recipe if I put DCM and what need to be changed if I put as someone said below DMSO and Toulene? I will be appreciate. With highest respect for the recepture you have posted I cannot get how in large scale production the 40-50% of yield can satisfy you?
Best regards
Best regards
- By William D.
For the test, you must mix BK4, dcm and methylamine as usual. You can add the amount of DMSO until the mixture becomes homogeneous. In this form, the reaction will be faster than usual. You control the reaction for the first time in temperature (when the mixture begins to cool, the reaction is finished, even without additional heating). After you add pure cold water and separate the lower layer and rinse again. Further steps are the same as you used (acidification with acetone or into the water layer)