Amphetamine Sulfate from reduction amination on P2P via amine formate

[Dr. X]

Hello! I wanna know if this reaction is possible -
Reagents:
P2P
Ammonia 10%
Formic acid 89%
MgSO4
Acetone
H2SO4

Synthesis:
Cold 10% NH3 solution is mixed with cold HCOOH 89%. Then is mixed with the P2P. The reaction leaves CO2 gas.
We make Amphetamine mix with water.
Salt Formation:
We use MgSO4 to dry the water as much as possible and then filtred out.
Cold anhydrous acetone is mixed with H2SO4 in 10:1 and mixed with the A-Oil with constant stiring, drop by drop till 5.5-7pH. Then filtred out.
Recrystalization:
Cold acetone is mixed again with the Amphetamine Sulfate for better cleaning and left in the fridge for 24 hours and then filtred and left to dry on air.
Yield %?,
If yes what are the proportion I should use?

 

[GhostChemist]

The scheme is not correct in names of some chemicals. Name of AMP is not verified (https://www.chemspider.com/Chemical-Structure.13852819.html)
O=O is not CO2

But method may be theoretically is working in this system, and CO2 must be deleted forcibly, because amine react with it

 

[Dr. X]

The O=O is my bad I draw it fast and I was sleepy. So about the CO2 how should it be removed? By NaOH extraction or smth else?

 

[GhostChemist]

Problem CO2 formed in the system, may be pass the nitrogen through solution... this process is similar to Leukart process and in the end may be had low yield.
May be using catalyst yield will be more than 50%.
We are working on classical Leukart and Leukart with catalysts and results will be present soon
http://bbzzzsvqcrqtki6umym6itiixfhn...phetamine-and-methamphetamine-smale-scale.47/

 

[LabPsycho]

Has anyone tested the method in Vogel's paper vol.5 in the Leuckart section that if you make Leuckart-type reaction with using ammonium acetate with P2P (instead formate or formamide), you would get amphetamine acetate salt, instead of the N-formylamine, that has to be hydrolyzed with acid or base? Can it even work? The paper claims the results with ...hmmm was it benzophenone or acetophenone.. still, it worked, skipping the hydrolyzing part of the og Leuckart's. It gave straight acetate salt of primary amine!

 

[GhostChemist]

Interesting material (write pls full title, journal, vol, pp, year) and need experimental check
Our team is working on these methods

 

[LabPsycho]

This was the part I was referring from (I remembered it wrong.. page: 322)

The use of acetic acid with ammonium formate at 155° is reported to result in the formation of the acetate salt of the primary amine rather than the formyl derivative; acetophenone and ammonium formate give a-formylaminoethylbenzene, while the addition of acetic acid is stated to lead to the formation of a-aminoethylbenzene acetate.

I can give this book if you don't have it here already.
It is Organic Reactions, Volume 5. by Roger Adams.

 

[LabPsycho]

So I remembered they tested the reactions with ammonium acetate, but it was ammonium formate in glacial acetic acid. It is around the same chapter where is Leuckart and Leuckart-type reactions made by Ingersoll, Moore, Wallach and Leuckart.