Efedrona do cloridrato de efedrina

[YenaneY]

Which other things could I possibly use as an oxidizing agent here?
Would it be possible with concentrated H2O2?
Also if H2O2 works, wouldn't it make it easier to isolate the product afterwards?

 

[DHHood]

Wont work.
Need kmno4, or better Chrome oxidizer, with chrome(III)OXIDE being the Best option

 

[Eleusius_hive_reboot]

it does work if specific conditions are precisely kept, i confirmed it analytical during synthesis and the resultin substance passed all analysis methods(reagent-colour tests) and of course the sweet odor and i flew high as a KITE

 

[DHHood]

Mit kaliumpermanganat funktioniert es auch, man muss nur exakt messen, genau timen und wissen wie giftige beiprodukte, sofern entstanden, zu entfernen sind. Dazu ist mehr als chemisches Grundwissen gefragt, obwohl die Synthese so simpel ist dass sie jeder durchführen kann.

Ich habe abzugeben :
* Chrome(III)oxide
* Kaliumpermanganate
* Ephedra sinica from China (2.5-5% ephedrine type alkaloids with l-ephedrine being the most with 90%
* I can offer extraction of ephedrine from the herb and deliver clear white ephedrine hcl extract which is of very high purity and can directly be used for further synths
* almost pure pseudoephedrine Extracted from pills and seperated from the ibuprofen also present in its pill form
... also i have 3-4g ephedrone methcathinone (made with l-eph&kmno4) to give away, maybe one would to thank by Sending a few Euros 4 IT. Should be basified and washed with Walter to remove excess salt which is in product.

Best regards
D

....

All chemicals Like acids (phosphoric, hcl, sulphur ect) , bases, oxidizing agents, iodine / Jod, alcohols like Ethanol, Methanol, Loesungs-/Reinigungsmittel dmso, Aceton, dcm methylene Chlorid, ether, terpentine, naphta, ipa, heptane and EVERY other can be offered by me, Text me if u need a quotation...

 

[KensonKen]

Dear DHHood - we look for a new vendor for Ephedrine Powder? Can you sell it?

 

[YenaneY]

Okay, but why will H2O2 not work? Or more generally no other oxidizer than kmno4 or Chrome oxidizer?

 

[DHHood]

Because u need an agent which oxidizes secondary alcohols to ketones, u cant just take anyone..... Also h2o2 is needed for the synth IT is Not an oxidizing agent, the ones u need are chromes in the +6 State f.e. chrome(VI) oxide, sodium/potassium/Ammonium dichromate ect... Look up Jones reagent for more Info

 

[YenaneY]

Okay thx, I oversaw that...
But regarding oxidizing agents that oxidize specifically secondary alcohols to ketones, I read sodium hypochlorite does?
Also i'm interested in you offer, I'll write dm

 

[DHHood]

IT May work with sodium hypo., i dont know..... But why Do that?

With chrome(VI)oxide u get a clean and pure product and this synthesis is the Status quovquo w detailed manuals, also will be finished in a couple hours...

Kmno4 works too, but will take over night and u have to watch out for manganese which is a byproduct and Really dangerous.

 

[Eleusius_hive_reboot]

PLEASE BELIEVE ME, HYDROGEN-PRROXIDE (3%) F. DRUGSTORE DOES THE JOB IN ACETIC ACID !

QUENCH WITH SODIUM-BISULFITE AND BOOM1 DONE

KmnO4 LEAVES TRACE AMOUNTS OF TOXIC BRAIN DAMAGING COMPOUNDS 1 VERY TRICKY TO GET IT OUT COMPLETELY, NOT A GOOD WORKUP...

 

[William D.]

Yes, many heads suffered from this. If you have a good method, publish please. The community will be grateful.

 

[Eleusius_hive_reboot]

i will re View this synth in near future, for this community....but i have other synthesis documentation ongoing before...what is certain....
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
I DID OXIDIZE THE m-CATHINONE DIRECTLY FROM EPHEDRA HERB EXTRACTION SOLUTION.

..I ACIDIFIED WITH 25% ACETIC ACID (BUFFERING) -

THEN SUBSEQUENT ->A FEW DROPS OF HOUSEHOLD PEROXIDE 3% I
.(SODIUM-HYPOCHLORITE SOLUTION WORKS ALSO; BUT ITS NASTIER:...)

STEADY MAGNETIC STIRRING WITH COOLING WATER BATH..

. -- QUENCHED WITH BISULFITE SOLUTION *

WORKUP AS USUAL = LIKE ANY PHENETHYLAMINE-[ A/B XTRACTING ]

STABLE SALT BY DILUTE ACID OF PREFFERENCE
_______________________________________________________________
OBTAINED A DECENT AMOUNT OF VERY PLEASANT SLIGHT PINK KETONE SWEET ODORING HYDROCHLORIDE SALT

 

[Noel]

It's true what William D says above: the community will be grateful.

With household hydrogen peroxide, I've twice tried and twice failed. And yet both times that I tried, I was never precisely certain what went wrong and why, when I thought I had it nailed.

 

[Eleusius_hive_reboot]

elaborate please, how you did it, and i`ll tell you what to do to get the desired product .

here are some factors, that are essential:

- did you start from ephedrine or Pseudoephedrine?

- did you use only very diluted and stablized H2O2 (with 10% H3PO4)?
-
- Did you use Sodium bisulfite, to quench (deactivate the oxidizing reraction)?

- did you use distilled Water & Acetic Acid as Reaction Medium ? (very important otherwise it fails)
_____________________________________________________________________________________________________________

On my side, i used TLC analytical methodology, during and after the Reaction...

confirming empirically , that this was indeed N-Methylcathinone-HCL
>>( also my anecdotal self ingestion, confirmed with a hyping rush...)

However, the first time it undergone, self racemization , because of the Keto-Enol tautomerism
(specialty about cathinones, in basic form, especially in alcoholic solution)

the second time i had fixed this Problem, by saturating the quenched reaction fluid
with sodium-chloride,
and then i used NaOH solution to raise the PH to free the aminoketone...

this was done while a solvent mixture of ethylacetate and Pet.-Ether -
-> already sat on top the aqueous Phase.
extraction of the base carried out quickly ! (all in an ice/acetone cooling bath, as well as ice cubes added to NaOH solution)

i extracted 2 further times with Naphtha (pet.-Ether C6H6) pooled the extracts and gave an aqueous layer to them, of 50 ml , this sank down of course, where i dropwise titrated down toPH 6~ to neutralize it for obtaining the stable HCL salt. the polarimetric testing showed optical purity of the desired isomer (dextro-m-cathinone)
--------------------------------------------------------------------------------------------------------

At the Moment i have to finish some other detailed Synthesis Protocols with visual documentated
step by step tutorials.....but i put this Method in queue...

But until then, please stop that Permanganate or chromium oxide ways....even though i am a pro clandestine chemist.... i dont dare to ingest some stuff that was produced that way....

 

[Noel]

Hey! I like your style, and I thank you for your thoughtful reply. In answer to your first question, I in both cases started with pseudoephedrine, and in both cases I was scrupulous in my measurements. I did not at any time use a microwave oven. I did use a thermometer. Also, on the first attempt I used the garden-variety 3% H2O2. Then, after crashing and burning, and after reading everything I could get my hands on (which wasn't much) and then interrogating my chemist friend Andy -- who's a professor of Analytical Chemistry and a guy of the sweetest, squarest, non-drug-using sort -- I went that second time with 12% H2O2. This wasn't Andy's suggestion. He was weary of me, and I had it in my head that this is where I'd fucked up.

But I do completely understand what you're saying above, and I can't tell you how helpful it is.

I didn't go about it the same both times around. The first time, I used acetone for the pseudo extraction. The second time I went with Naptha. But both times I did, as you ask above, deactivate the process of oxidization with sodium bisulfite.

What I didn't do, however, is the thing you most recommend: I didn't use glacial acetic acid as my reaction medium. I used sulfuric acid in the form of a drain-cleaner called Zep (98%)! Pathetic, I know, and embarrassing. But that was so long ago! I've wised-up, thanks to excellent people like you.

 

[Eleusius_hive_reboot]

ok my dear,

its okay, dont be embarassed....you cant imagine what people sometimes ask on here...but
no matter your skill level, you seem to be reflective and thoughtfull at least....

SO:

- Dont need to use glacial acetic acid, grocery store (25%) white vinegar concentrate works!

- This reaction needs to be done in cold condition

- what pills formulation did u extract the PSE out of? (ingredients other than pse....)

- how did you apply the bisulfite? (dissolve in water first!)

- You described, a Naphtha extraction of pills, do you mean, you based the pill mass and extracted the freebase ? (otherwise you didn't get pse out, because its a hydrochloride and insoluble in non-polar solvents )

- in case you did extract by basing, did you convert it back via Hydrochloric acid (muriatic acid at stores)

------------------------------------------------------------------------------------------------------------------------

Here are some hints, based on your fails...

QUICK GENERAL GUIDING NO EXACT TUTORIAL !!!! BUT GETS PRODUCT IF THE PSEUDO IS PROPERLY
cLEAN EXTRACTED AND PREPARED.....ITS PRETTY GHETTO; BUT LETS STAY HONEST; MOST PEOPLE WANT TO DO THAT SHIT EASY AND CRAVING PRODUCT. I CAN EMPHATIZE AND DONT THINK MY NOSE IS UP IN HEAVEN.... BUT THE STIRPLATE IS A UNAVOIDABLE TOOOL IF YOU WANT TO SUCCEED BUT THERE ARE GOOD CHEAP ONES ON AMAZON NOW!
[2 500ml beakers + 2-3 100ml beakers + 2 20ml syringes + 12ml syringe is the least thats neccesary use kitchen-lab glassware, no masonjars AND NO CONTAINERS WHERE FOOD IS INGESTED OF avoid unresponsible behaviour, please.]

********************************************************************************************************
so follow wisely folks:

dont be sad, important is, to learn from mistakes and even a failed attempt, brings you closer to get result...to get chemistry right, you cant go around to learn observing/reacting->developing a sense for your reagents and the right conditions.

please weigh and scale ...dont need sophisticated gear for this specific Task... a Beaker, some syringes with scale ....protective gear<<gloves eye protection and all that.

use the 3% one....but DILUTE it even further, and depending on how much starting material you want to oxidize....adjust the ratio-> USE: a beaker , 35ml DH2O/ 35ml H2O2 stablized, 3% (drugstore version)
--> mix it in the small beaker (pre -reaction) then dilute your pseudo in ethanol (very small amount, just to dissolve better)

make a 500 ml Beaker your reaction Vessel, prepare it with 100mlDH2O + 150ml Acetic Acid 25% ....Diluted pseudo should added at once. STIR thoroughly !!!! (buy a cheap magnetic stirplate for 60$ on amazon!)

prepare ice cubes and make a ice/ water bath filled container for your reaction vessel troughout the process, to control the selective oxidation...take a syringe (12ml) and fill it up....splash 6ml in the RM- while the magnetic stirrer is moderately running.

let it stir 5minutes....then turn off....let it react 20 mins....then repeat with the rest of the syringes mix..

do this three times (3x 12ml with mixed oxidant, in 2 equal parts...like above)

if you did all that (last 20min-reaction time over....) stir the hell out of the soup....meanwhile prepare your bisulfite solution....quench (there is something called corn starch test...lookitup)
it shows the "oxidation status" of sort...is it negative then ---> add 50ml naptha & COLD NaOH solution, until PH13....stir and let it seperate + colllect the naphta-freebase mix in a second vessel (use syringes to seperate, be careful only naphta not the r-fluid (aqueous-phase)


do 2 more extractings with same amount naptha. .....now add to the naptha poolings around 100ml of water and drop Hydrochloric acid (5% diluted to) a few drops ...STIR vigorously with plate... . grab a glass rod, dip it in die lower aqua phase, pull it up and push on to a ph paper(tip a few times, like you`d knock on a door ...)

do this procedure (called titration) until you reached PH 5,5....then discard naphtha (save, its reusable!) and the acidic water (which hopefully contains M-Cat you should put in a pyrex dish and gently boil it down- not to much heat!!! at the end, when it thickens-> throw a generous amount of acetone in & use a electric handheld fan device, to blow the remaining liquid quicker away....


scrape the crude hcl salt of M-Cath from bottom and rinse in the dish 3 times with dry acetone. collect this elsewhere, it crystalizes more cathinone out if you let stand openly...

let the salt dry and--ENJOY ---> ALREADY IN THE VAPING DOWN PROCESS YOU SHOULD SMELL KETONE ODOR...

its pleasant, sweet, like roses or some people say different fruit aromas....i find it speedy, like the phenylacetone from european speed(also a ketone)

I HOPE THIS IS VALUABLE FOR SOME FOLKS... until i make a top notch experimet journal with pictures, try this instead the toxic other routes !

STAY SAFE
BE NICE

ELEUSIFY YOUR KITCHEN and have a nice buzz if you succed by my guide
--->!
send a appreciation prayer out in the ether of the universe....
for your old Homie with the gasmask....( he`s probably smoking meth then ;-)

CHEERS

 

[Noel]

If the truest measure of intelligence is found in the ability to cooly bring even the most complex subject-matter down to a level of complete comprehensibility -- as I believe it is -- you then, Mr. Eleusius, do your name justice*: because you're one smart cool cat.

_______________________________________________________________________________________________

*The city of Eleusis, named after the man Eleusis (son of the Hermes), is most famous for the Eleusisian Mysteries, which are believed by many to have hinged upon the consuming of a psychoactive substance which brought about indescribable enlightenment, and about which my main motherfucker Cicero wrote:

"For it appears to me that among the many exceptional and divine things your Athens has produced and contributed to human life, nothing is better than those [Eleusisian] Mysteries. For by means of them we have transformed from a rough and savage way of life to the state of humanity, and have been civilized. Just as they are called 'initiations,' so in actual fact we have learned from them the fundamentals of life, and have grasped the basis not only for living with joy but also for dying with a better hope."

 

[Eleusius_hive_reboot]

you`re VERY WELCOME my dear fellow,

THANK YOU FOR THAT RESPONSE !!!!
its right, i really try to convey complex subjects in to
everymans terms of understanding, i mean why not... even i have a Ph.D
though found only kindred spirits in the world of clandestine Chemists & Psychonauts.
---------------------------------------------------------------------------------------------
to honour my Rolemodel:

the sweet humble "STRIKE" who invented the first internet HUB for like-minded clandestine Chemists. called : " THE - HIVE "
may he bee extracting honey in freedom ever After....

" i have to train 1000s of people to be top notch ecstasy chemists - so much so, that the streets will be flooded, and the war on drugs is ENDING there ..."

that being said, I GOT GOOSEBUMPS FROM YOUR APPRECIATION COMMENT
ESPECIALLY THAT YOU CITED PASSAGES FROM THE SECRETS OF ELEUSIS -
WERE MY LEGACY WAS COMING FROM ( AND A FORMER HIVE USER WHO
GAVE ME THE WISDOM...)

You my Friend made my DAY, THANK YOU, sweet Noel !