LSD Toxicity and Lethal Dose

[HIGGS BOSSON]

LSD Toxicity and Lethal Dosage

The toxicity of LSD has been studied across multiple animal species. The standard toxicity measurement is the LD-50 index - the median lethal dose at which 50% of test subjects die. For LSD, this value varies significantly between species:

• Mice: 50-60 mg/kg (intravenous administration)
• Rats: 16.5 mg/kg
• Rabbits: 0.3 mg/kg

A documented case involved an elephant that died minutes after receiving 0.297 grams of LSD. With an estimated weight of 5,000 kg, this equates to 0.06 mg/kg. While this single case shouldn't be generalized, it suggests proportional sensitivity - the elephant's lethal dose was approximately 1,000 times lower than that of mice.

Most animal fatalities from LSD result from respiratory arrest.

These small lethal doses might suggest high toxicity. However, when compared to the human effective dose (0.0003-0.001 mg/kg), LSD demonstrates remarkably low toxicity. A lethal human dose would require:

• 300-600 times the effective dose (based on rabbit data)
• 50,000-100,000 times the effective dose (based on mouse data)

These comparative toxicity estimates should be understood as approximate magnitude assessments, as therapeutic index (the ratio between effective and lethal doses) only has meaning within specific species.

Human Safety Profile
No confirmed human deaths have resulted directly from LSD toxicity. The primary risks involve unpredictable psychological effects rather than physical toxicity.

Chromosomal and Teratogenic Effects
Early reports in popular media suggested LSD causes chromosomal damage and birth defects. However, comprehensive follow-up studies with statistically significant sample sizes found:

• No correlation between LSD use and chromosomal abnormalities
• No evidence linking LSD to fetal deformities in pregnant users

Given the millions of LSD users worldwide, such effects would have become evident if they existed. The original claims were based on isolated, unverified case reports.

 

[mycelium]

During my younger years, the people with whom I spent my time were involved in the LSD trade, actually, they WERE the LSD trade. According to the DEA, the grateful dead family was responsible for 80% of the LSD in the USA.
anyways, I did a half of a vial of wash(the liquid that goes on paper, about 4x the strength of "liquid acid", as a drop covers about 1/2"x1/2" on paper) anyways, I know 2 cousins that split a 10pack(1000 doses). Many people did "fingerprints" or "thumbprints", consuming about a tenth of a gram my sticking your wet finger in the jar of crystal LSD.
And a dude named "Saint Paul" raped some chick at a dead show, or some event. And she was 'somebody', the chemists sister, or girlfriend, or someone to the family...so someone shoved a gram in his mouth.
This happened years before I came on the scene, and at the time of my arrest he was still needing a babysitter. Permanently tripping, probably.

But have never heard of someone dying.

Some chick did a line and she thought it was coke but it wasn't, ended up being a half of a 10pack.

This Is What Happens When You Take 550 Doses of LSD At Once

Accidental LSD overdoses are not fun. But for some, they can have a bizarrely beneficial effect.

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